Search Results for: Stage

February 20, 2025February 20, 2025

Multi-technique-based electrochemical sensing of lipoarabinomannan (LAM) antigen as a biomarker for early-stage tuberculosis diagnosis.

Publication date: Feb 19, 2025 Tuberculosis (TB) remains a pressing global health challenge, necessitating precise and reliable biomarkers for early detection. Lipoarabinomannan (LAM), an FDA-approved biomarker (Monoclonal Antibody-MBS320597), holds significant ... Read more

January 21, 2025January 21, 2025

The clinical-stage drug BTZ-043 accumulates in murine tuberculosis lesions and efficiently acts against Mycobacterium tuberculosis.

Tuberculosis Literature

Publication date: Jan 18, 2025 The development of granulomas with central necrosis harboring Mycobacterium tuberculosis (Mtb) is the hallmark of human tuberculosis (TB). New anti-TB therapies need to effectively penetrate ... Read more

March 5, 2025March 5, 2025

S-nitrosylation-triggered secretion of mycobacterial PknG leads to phosphorylation of SODD to prevent apoptosis of infected macrophages.

Tuberculosis Literature

Publication date: Mar 11, 2025 The tuberculosis-causing agent Mycobacterium tuberculosis (M. tb) establishes its niche inside macrophages by secretion of several virulence factors and engaging many host factors. Mycobacterial infection ... Read more

March 2, 2025March 2, 2025

Blood levels of Mycobacterium tuberculosis (Mtb)antigen-triggered immune markers in people exposed to tuberculosis with regard to Mtb infection status and receipt of tuberculosis preventive therapy.

Tuberculosis Literature

Publication date: Mar 01, 2025 Interferon-γ release assays (IGRAs) for tuberculosis infection (TBI) cannot distinguish different stages of the TBI spectrum (including spontaneously cleared infection). We investigated patterns of Mtb-specific ... Read more

March 2, 2025March 2, 2025

Prenatal exposure to HIV pre-exposure prophylaxis and birth, growth, and social-emotional developmental outcomes throughout early childhood in Kenya: a prospective cohort study.

Tuberculosis Literature

Publication date: Mar 01, 2025 As pre-exposure prophylaxis (PrEP) implementation continues to scale up among pregnant people, accruing safety data following prenatal PrEP exposure remains important. In this study, we ... Read more

March 2, 2025March 2, 2025

Mortality in chronic pulmonary aspergillosis: a systematic review and individual patient data meta-analysis.

Tuberculosis Literature

Publication date: Mar 01, 2025 Despite antifungal treatment, chronic pulmonary aspergillosis (CPA) is associated with substantial morbidity and mortality. We conducted a systematic review and meta-analysis to evaluate rates of ... Read more

February 28, 2025February 28, 2025

What Causes Bilateral Pleural Effusion: A Case Report.

Tuberculosis Literature

Publication date: Mar 01, 2025 Tuberculous pericarditis begins with fibrinous and hemorrhagic pericarditis, followed by pericardial effusion, then pericardial hypertrophy, which may turn into subacute or chronic stage, and partly ... Read more

February 26, 2025February 26, 2025

mHealth intervention (mTB-Tobacco) for smoking cessation in people with drug-sensitive pulmonary tuberculosis in Bangladesh and Pakistan: protocol for an adaptive design, cluster randomised controlled trial (Quit4TB).

Tuberculosis Literature

Publication date: Feb 25, 2025 People with tuberculosis (TB) who continue to smoke are more likely to have poor health outcomes than those who quit. Established smoking cessation approaches such ... Read more

February 24, 2025February 24, 2025

The safety assessment of ustekinumab on psoriasis and psoriatic arthritis: A real-world analysis based on the FDA adverse event reporting system database.

Tuberculosis Literature

Publication date: Feb 22, 2025 To assess safety of ustekinumab (UST) on treatment of patients with psoriasis and psoriatic arthritis (PsA) by analyze UST related adverse drug events (ADEs). Data ... Read more

February 23, 2025February 23, 2025

Barriers and facilitators to tuberculosis service access for patients in Bajhang, Nepal: a qualitative study based on focus groups with patients, screening camp visitors, community volunteers and medical doctors.

Tuberculosis Literature

Publication date: Feb 21, 2025 Efforts to achieve global tuberculosis (TB) targets, especially in lower- and middle-income countries, such as Nepal, require urgent attention. Challenges persist, including TB-related social stigma ... Read more