Publication date: May 25, 2025 Macroautophagy (autophagy) is an evolutionarily conserved process that degrades excess cytoplasmic components, such as protein aggregates and damaged organelles, by encapsulating them within double-membrane autophagosomes. ... Read more

Publication date: May 09, 2025 Galectins form a protein family with a conserved carbohydrate-binding domain that specifically interacts with β-galactoside-containing glycoconjugates, which are found abundantly on mammalian cell surfaces. These ... Read more

Publication date: Jul 01, 2025 Mitochondria form an integral, yet frequently underappreciated, part of the immune response to Mycobacterium tuberculosis (M. tb), particularly within macrophages. Despite growing recognition for their ... Read more

Publication date: Jul 01, 2025 Tuberculosis (TB) is the leading cause of infectious disease mortality worldwide. Numerous host blood-based gene expression signatures have been proposed in the literature as alternative ... Read more

Publication date: Aug 01, 2025 The development of improved anti-tuberculosis (TB) strategies to address drug-resistance and ineffectual TB treatment regimens should focus on interrupting the initial host-pathogen interaction. This study ... Read more

Publication date: Jun 06, 2025 Despite the prevalence of co-infection with drug-sensitive and drug-resistant Mycobacterium tuberculosis strains within a single host, the implications of such dual infections remain poorly understood. ... Read more

Publication date: Jun 05, 2025 Oxidative phosphorylation has emerged as a critical therapeutic vulnerability of M. tuberculosis (Mtb). However, it is unknown how intracellular bacterial pathogens such as Mtb maintain ... Read more

Publication date: Jun 02, 2025 The risk and prognosis of tuberculosis (TB) are influenced by a complex interplay between human and bacterial genetic factors. While previous genomic studies have largely ... Read more

Publication date: May 28, 2025 Mycobacterium tuberculosis (M. tuberculosis), the causative agent of tuberculosis (TB), remains a leading global health threat, exacerbated by rising drug resistance and the ability of ... Read more

Publication date: May 27, 2025 New treatments are still necessary to eradicate tuberculosis disease. Macrophages derived from human induced pluripotent stem cells (hiPSC-Macs) offer a physiological niche to identify potential ... Read more