Search Results for: Clinical
Rare bilateral corneoscleral perforation secondary to ocular tuberculosis: a case report and clinical insights.
Tuberculosis Literature
Publication date: Mar 05, 2025 This case represents a rare presentation of bilateral corneoscleral perforation secondary to presumed ocular mycobacterium tuberculosis infection with the goal of reporting a case of ... Read more
Predicting tuberculosis drug efficacy in preclinical and clinical models from in vitro data.
Tuberculosis Literature
Publication date: Mar 21, 2025 Multiple in vitro potency assays are used to evaluate compounds against Mycobacterium tuberculosis, but a consensus on clinically relevant assays is lacking. We aimed to ... Read more
Completion of tuberculosis preventive treatment with 300 mg vs. 100 mg isoniazid tablets: a pragmatic randomized clinical trial.
Tuberculosis Literature
Publication date: Mar 03, 2025 Monotherapy with the drug isoniazid (INH) was for a long time the main therapeutic regimen used for tuberculosis preventive treatment (TPT). Research is progressing into ... Read more
Preclinical model of Mycobacteroides abscessus lung disease by nose-only exposure of mice to bacterial powder aerosol.
Tuberculosis Literature
Publication date: Mar 01, 2025 The limitations of existing mouse models of lung infection with Mycobacteroides abscessus impede drug discovery and development. In contrast to current animal models that introduce ... Read more
Prevalence and genetic insights of linezolid resistance in tuberculosis: A study of sensitive and resistant clinical isolates.
Tuberculosis Literature
Publication date: Mar 01, 2025 Despite undiagnosed tuberculosis cases, it remains a major global health issue, complicated by antibiotic resistance. Linezolid has been approved for multidrug-resistant (MDR) TB management, but ... Read more
Tuberculous meningitis as an underlying cause of rapid neurological deterioration in a patient with a history of psychiatric disorder: Clinical case report.
Tuberculosis Literature
Publication date: Mar 01, 2025 Tuberculous meningitis (TBM), the least common of extrapulmonary tuberculosis presentations, one of the most severe. Highly prevalent in immunosuppressed individuals it is associated with high ... Read more
In vitro activity of omadacycline against geographically diverse rapidly growing nontuberculous mycobacteria (NTM) clinical isolates.
Tuberculosis Literature
Publication date: Mar 01, 2025 Nontuberculous mycobacteria (NTM) are emerging opportunistic pathogens with limited treatment options due to resistance to multiple antibiotic classes. This study aimed to evaluate the in ... Read more
Clinical evaluation of computer-aided digital x-ray detection of pulmonary tuberculosis during community-based screening or active case-finding: a case-control study.
Tuberculosis Literature
Publication date: Mar 01, 2025 Computer-aided detection (CAD) has been recommended as a tuberculosis screening tool. However, there are limited data about its utility, specifically in a community-based setting where ... Read more
Clinical value of Metagenomic Next- and Third-Generation Sequencing applied in ultrasound-guided puncture biopsy for diagnosing lymph node tuberculosis.
Tuberculosis Literature
Publication date: Jan 04, 2025 The aim of this study was to assess the clinical utility of metagenomic next-generation sequencing (mNGS) and metagenomic third-generation sequencing (mTGS) in diagnosing cervical lymph ... Read more