Search Results for: Bedaquiline

September 5, 2026

Genomic and structural insights into the atpB L173I substitution: modulation of the F₀ rotor architecture in Mycobacterium tuberculosis ATP synthase and altered Bedaquiline binding dynamics.

Publication date: Sep 03, 2026 The F₀F₁ ATP synthase of Mycobacterium tuberculosis (M. tuberculosis) is an essential membrane-embedded rotary motor responsible for ATP synthesis and maintenance of the proton motive ... Read more

September 4, 2026

Treatment of multidrug-resistant tuberculosis with bedaquiline, pretomanid, linezolid, and moxifloxacin following near-total gastrectomy.

Tuberculosis Literature

Publication date: Sep 01, 2026 Patients with a history of gastrectomy are at increased risk of developing pulmonary tuberculosis due to nutritional deficiencies and potential immune impairment. Altered gastrointestinal anatomy ... Read more

September 3, 2026

Treatment of multidrug-resistant tuberculosis with bedaquiline, pretomanid, linezolid, and moxifloxacin following near-total gastrectomy.

Tuberculosis Literature

August 30, 2026

Effectiveness of Bedaquiline-, Delamanid- and Linezolid-Containing Regimens in Improving Treatment Outcomes Among Pediatric and Adolescents With Drug-Resistant Tuberculosis in the Country of Georgia.

Tuberculosis Literature

Publication date: Aug 28, 2026 Formulating effective regimens to treat children with drug-resistant tuberculosis (TB) remains a great challenge. We aimed to compare treatment outcomes among children treated with regimens ... Read more

August 27, 2026

Successful Translational Prediction of Bedaquiline’s Phase 2a Clinical Trial Results against Tuberculosis: The Zebrafish as a New Approach Methodology.

Tuberculosis Literature

Publication date: Aug 24, 2026 Tuberculosis remains an urgent global health crisis that requires an accelerated development of novel regimens. Rodent and rabbit studies currently inform early translational predictions. However, ... Read more

August 6, 2026

In vitro characterization of GSK2556286 in combination with bedaquiline and pretomanid against Mycobacterium tuberculosis.

Tuberculosis Literature

Publication date: Aug 05, 2026 GSK2556286 (GSK286) is a novel drug candidate with a cholesterol-dependent mode of action that has shown promising in vivo potential to improve tuberculosis treatment when ... Read more

August 1, 2026

Cerebrospinal Fluid Concentrations of Bedaquiline, Pretomanid, and Linezolid During Curative Treatment of Fluoroquinolone-Resistant Pre-Extensively Drug-Resistant Tuberculous Meningitis.

Tuberculosis Literature

Publication date: Jul 01, 2026 Bedaquiline, pretomanid, and linezolid (BPaL) is a 6-month regimen that has revolutionized treatment of multidrug-resistant (MDR) tuberculosis (TB). However, there is limited evidence of using ... Read more

August 1, 2026

Analytical Method Development and Validation for Clofazimine in Human Plasma and Application of LC-MS/MS Based Methods for Clofazimine and Bedaquiline in Indian MDR-TB Patients Stratified by HIV Coinfection.

Tuberculosis Literature

Publication date: Aug 01, 2026 Multidrug-resistant tuberculosis (MDR-TB) remains a major cause of morbidity and mortality worldwide, with people living with HIV experiencing persistently poor treatment outcomes. Clofazimine and bedaquiline ... Read more

July 30, 2026

No phenotypic resistance observed for most group-3 and -4 variants in Mycobacterium tuberculosis genes related to bedaquiline, clofazimine, delamanid, and pretomanid in a Central and West African context.

Tuberculosis Literature

Publication date: Jul 28, 2026 The interpretation of genetic variants’ association (or not) with phenotypic resistance to newly introduced and repurposed antituberculosis drugs remains challenging, as many mutations detected by ... Read more

July 25, 2026

Cost-effectiveness evaluation of bedaquiline- and delamanid-containing regimens for multidrug-/rifampicin-resistant tuberculosis in China: a retrospective study based on three nationwide, real-world multicenter cohorts.

Tuberculosis Literature

Publication date: Apr 30, 2026 Bedaquiline and delamanid are novel anti-tuberculosis drugs approved in China and recommended by the World Health Organization, with demonstrated good efficacy and safety profile in ... Read more