Publication date: Jan 29, 2026
Sarcoidosis is a multisystem granulomatous disease that can mimic tuberculosis (TB) or lymphoma, particularly in endemic regions. We report a man in his late 50s with chronic cough, weight loss and systemic features whose CT showed mediastinal and abdominal lymphadenopathy with splenic lesions. Histology from endobronchial ultrasound-guided transbronchial cryobiopsy revealed non-caseating granulomas, confirming sarcoidosis and excluding TB and malignancy. He responded well to corticosteroids with methotrexate as a steroid-sparing agent. This case emphasises the diagnostic challenge of sarcoidosis in TB-endemic regions and highlights the added value of cryobiopsy in obtaining adequate tissue for diagnosis.
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | sarcoidosis |
| disease | MESH | tuberculosis |
| pathway | KEGG | Tuberculosis |
| disease | MESH | lymphoma |
| disease | MESH | chronic cough |
| disease | MESH | weight loss |
| disease | MESH | lymphadenopathy |
| disease | MESH | granulomas |
| disease | MESH | malignancy |
| drug | DRUGBANK | Methotrexate |
| disease | MESH | Interstitial lung disease |