Publication date: Jan 07, 2026
This study aimed to characterize the clinical profiles of patients hospitalized with chikungunya fever in Shunde, China (2025), and to use time-to-event analysis to identify predictors of prolonged viral clearance. A retrospective cohort study included 1,721 confirmed chikungunya patients from July to August 2025. Patients were stratified by age and comorbidities. Disease course was classified as regular (≤7 days) or prolonged (>7 days). Cox proportional hazards regression was used to identify factors independently associated with the time to viral RNA clearance. The cohort (mean age 43. 6+/-21. 8 years) exhibited high frequencies of key symptoms: fever (88. 4%), arthralgia (88. 3%), and rash (71. 4%). Clinical profiles differed significantly by age: pediatric cases (n=276) had more prominent fever, whereas arthralgia duration increased and viral clearance slowed progressively from pediatric to adult to geriatric groups (median clearance: pediatric 5 days vs. geriatric 8 days, all log-rank P7 days) occurred in 13. 7% of patients (n=235/1,721) and was independently associated with advanced age (HR=0. 994, P
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| Concepts | Keywords |
|---|---|
| China | Age Factors |
| Fever | Chikungunya Fever |
| Geriatric | Comorbidity |
| July | Disease Outbreaks |
| Risk Factors |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | chikungunya fever |
| disease | MESH | included |
| disease | MESH | fever |
| disease | MESH | arthralgia |
| disease | MESH | rash |
| drug | DRUGBANK | Guanosine |
| disease | MESH | Infectious Diseases |
| drug | DRUGBANK | Coenzyme M |
| pathway | REACTOME | Metabolism |