Publication date: Nov 28, 2025
This study of a measles-vectored vaccine for chikungunya virus (MV-CHIK) was a Phase 1 randomized, double-blinded, placebo-controlled trial with varying intervals between the 2 doses. The 6 cohorts each had 30 subjects, of which 25 received MV-CHIK and 5 received placebo. The 5 cD7 105 TCID50 dose was superior to the 5 cD7 104 TCID50 dose, and longer dosing intervals resulted in higher titers in the high dose groups. Mild to moderate injection site and systemic reactogenicity was common but brief. There was no evidence of prolonged vaccine-related arthralgia.
| Concepts | Keywords |
|---|---|
| chikungunya | |
| measles-vectored vaccine | |
| phase 1 trial | |
| vaccine | |
| “”” | |
| // Werkzeug Debugger | |
| EVALEX = false, | |
| EVALEX_TRUSTED = false, | |
| in __call__ | |
| line 1536, | |
| NotImplementedError |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | Measles |
| pathway | KEGG | Measles |
| disease | MESH | arthralgia |