Publication date: Nov 01, 2025
In 2023, almost 200,000 children under 15 years died from tuberculosis, most without appropriate treatment. Treatment decision algorithms (TDAs), developed to facilitate rapid anti-tuberculosis treatment initiation in children, were recommended by the World Health Organization (WHO) in 2022, conditional on validation in different cohorts and settings. We performed a retrospective external evaluation of WHO TDAs using an individual participant dataset (IPD). The IPD comprised four paediatric cohorts, restricted to children with presumptive pulmonary TB
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Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | tuberculosis |
| pathway | KEGG | Tuberculosis |
| disease | IDO | history |
| disease | IDO | process |
| disease | MESH | Infectious Diseases |
| disease | MESH | Infection |
| pathway | REACTOME | Infectious disease |
| disease | IDO | infectious disease |
| drug | DRUGBANK | Ademetionine |
| disease | IDO | algorithm |
| disease | MESH | nutritional status |
| disease | MESH | HIV Infections |
| disease | MESH | Tuberculosis Pulmonary |