Publication date: Oct 31, 2025
Despite heavy exposure to Mycobacterium tuberculosis (Mtb), some individuals are resistant to TST and IGRA conversion (RSTRs). The functional and immunological mechanisms governing resistance are poorly understood. We hypothesized that RSTR and LTBI alveolar macrophages (AMs) respond differently to Mtb infection with transcriptional programs that are distinct from peripheral blood monocytes. We examined media and Mtb-infected AMs from bronchoalveolar lavage fluid collected from a RSTR cohort in Uganda with over 10 years of clinical follow-up. With transcriptional profiles of BAL cells analyzed immediately after collection, gene set enrichment analysis (GSEA) revealed 13 differentially expressed gene sets between RSTR (n = 19) and LTBI (n = 26) groups, including one (Hallmark E2F targets) which was positively enriched in the RSTR group (FDR
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Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | infection |
| disease | IDO | blood |
| drug | DRUGBANK | Dimercaprol |
| pathway | REACTOME | Reproduction |
| drug | DRUGBANK | Coenzyme M |
| disease | MESH | Latent Tuberculosis |
| disease | MESH | Tuberculosis |
| pathway | KEGG | Tuberculosis |