Publication date: Aug 01, 2025
Tuberculosis (TB) remains a significant public health concern, particularly in congregate settings such as schools, where adolescents are at increased risk transmission. This study aimed to investigate the epidemiological characteristics, transmission dynamics, and control strategies during a TB outbreak in a South Korean high school. A retrospective epidemiological investigation was conducted using data from the Korea Tuberculosis Network and official outbreak reports. A total of 935 individuals-including students, staff, and household contacts-underwent screening through chest X-rays, interferon-gamma release assays (IGRAs), and chest computed tomography (CT). Genotyping of Mycobacterium tuberculosis isolates was performed using spoligotyping and whole-genome sequencing (WGS). Logistic regression identified risk factors associated with TB infection. Among 935 contacts, 133 (14. 2%) tested positive for TB infection. In total, 30 cases of TB disease and 66 cases of latent TB infection were identified among 762 student contacts. Prolonged exposure exceeding 10 hours per week was associated with a significantly increased risk of TB infection (adjusted odds ratio = 5. 91, 95% confidence interval: 3. 06-11. 40, P
| Concepts | Keywords |
|---|---|
| Beijing | epidemiologic investigation |
| Genotyping | school-based transmission |
| Korea | subclinical tuberculosis |
| Tomography | tuberculosis outbreak |
| Tuberculosis |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | Tuberculosis |
| pathway | KEGG | Tuberculosis |
| drug | DRUGBANK | Etoperidone |
| pathway | REACTOME | Release |
| disease | MESH | infection |
| disease | MESH | latent tuberculosis infection |