Publication date: Sep 19, 2025
Genetic associations within the human leukocyte antigen (HLA) gene complex and linked genes in TB-IRIS outcomes remains population specific and not well understood. Here, we conducted a study including well characterised HIV-TB coinfected patients with (n = 86) and without (n = 124) TB-IRIS from the randomized, double-blind, prophylactic prednisone trial (PredART study) with HLA, ERAP and KIR genotyping data. We confirmed the association of TB-IRIS with lower CD4 counts pre-ART initiation. We identified nine classical class I and II HLA alleles protective against TB-IRIS, while four alleles were linked to increased risk. Associations ranged from strongly protective (HLA-DQB1*05:01, OR: 0. 07, 95%CI: 0. 02-0. 28, Pc
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| Concepts | Keywords |
|---|---|
| Cd4 | Alleles |
| Genetic | Associated |
| Iris | Class |
| Tuberculosis | Genetic |
| Hla | |
| Immune | |
| Inflammatory | |
| Iris | |
| Leukocyte | |
| Linked | |
| Protective | |
| Reconstitution | |
| Syndrome | |
| Tb | |
| Tuberculosis |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | tuberculosis |
| pathway | KEGG | Tuberculosis |
| disease | MESH | immune reconstitution inflammatory syndrome |
| drug | DRUGBANK | Prednisone |
| pathway | REACTOME | Reproduction |
| disease | MESH | Allergy |
| disease | MESH | Infectious Diseases |