Drug resistance of Mycobacterium tuberculosis to linezolid and delamanid: a case report from Bukavu, Democratic Republic of Congo.

Publication date: Jul 12, 2025

The emergence of resistance is of great concern in the control of TB, especially to the new and repurposed drugs needed for the treatment of rifampicin resistance. We report a patient from South Kivu in the Eastern Democratic Republic of the Congo with primary resistance to delamanid and linezolid without treatment experience with these drugs. The identification of novel resistance mutations raises concerns about the potential global spread and poor outcomes of the WHO-recommended oral treatment regimens, highlighting the need for the urgent rollout of DST.

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Concepts Keywords
Democratic Adult
Drugs Antitubercular Agents
Mycobacterium Antitubercular Agents
Tuberculosis Drug resistance
Urgent Drug Resistance, Bacterial
Female
Humans
Linezolid
Linezolid
Linezolid and Delamanid
Male
Microbial Sensitivity Tests
Mycobacterium tuberculosis
Nitroimidazoles
Nitroimidazoles
Novel mutations
OPC-67683
Oxazoles
Oxazoles
Tuberculosis, Multidrug-Resistant

Semantics

Type Source Name
drug DRUGBANK Linezolid
drug DRUGBANK Delamanid
drug DRUGBANK Rifampicin
drug DRUGBANK Dihydrostreptomycin
pathway REACTOME Reproduction
disease MESH Infectious Diseases
disease MESH tuberculosis
pathway KEGG Tuberculosis
disease MESH morbidity
drug DRUGBANK Bedaquiline
disease IDO susceptibility
pathway KEGG Mycolic acid biosynthesis
drug DRUGBANK Coenzyme F420
drug DRUGBANK Coenzyme M
drug DRUGBANK Pretomanid
disease MESH treatment failure
disease MESH relapse
drug DRUGBANK Isoniazid
drug DRUGBANK Pyrazinamide
drug DRUGBANK Ethambutol
drug DRUGBANK Trestolone
drug DRUGBANK Streptomycin
disease IDO drug susceptibility
disease IDO assay
drug DRUGBANK Tromethamine
drug DRUGBANK Edetic Acid
drug DRUGBANK Clofazimine
drug DRUGBANK Imidazole
drug DRUGBANK Methyl isocyanate
pathway REACTOME Metabolism
disease IDO cell
disease IDO bacteria
disease MESH AIDS
drug DRUGBANK (S)-Des-Me-Ampa
drug DRUGBANK Rifapentine
drug DRUGBANK Rifabutin
drug DRUGBANK L-Leucine
disease MESH Tuberculosis Multidrug-Resistant

Original Article

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