Publication date: May 20, 2025
Tuberculosis (TB) and human immunodeficiency virus (HIV) represent important public health problems. Suppression of the immune system, due to both diseases, predisposes to the development of opportunistic infections, such as invasive fungal infections (IFI). The aims of this study were to determine the frequence of investigation of invasive fungal infection (IFI) in TB/HIV co-infected patients, identify the most frequent IFI and evaluate the clinical-epidemiological characteristics of TB/HIV/IFI patients. A descriptive and retrospective study was conducted including patients assisted at Hospital Dr. Miguel Riet CorrcEAa Jr. (HU-FURG/Ebserh), in Rio Grande city, southern Brazil. All patients diagnosed with TB/HIV from 2017 to 2022 were included, and databases were analyzed for data regarding mycological exams for fungal diseases investigation. Of the 194 TB/HIV coinfected patients, 77. 8% (n = 151) were investigated for at least one IFI. Co-infection was confirmed in16. 7% (25/151), being 44% (n = 11) of the patients diagnosed with cryptococcosis, followed by histoplasmosis (40%; n = 10) and colonization/infection by Aspergillus (32%; n = 8). Furthermore, some patients presented more than one fungal co-infection (16%; n = 4). CD4 T cell count
| Concepts | Keywords |
|---|---|
| Brazil | Aspergillosis |
| Cd4 | Cryptococcosis |
| Immunodeficiency | Histoplasmosis |
| Mycological | HIV |
| Tuberculosis | Mycobacterium tuberculosis |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | invasive fungal infection |
| disease | MESH | tuberculosis |
| pathway | KEGG | Tuberculosis |
| disease | IDO | immunodeficiency |
| pathway | REACTOME | Immune System |
| disease | MESH | opportunistic infections |
| disease | IDO | infection |
| drug | DRUGBANK | Ribostamycin |
| disease | MESH | fungal diseases |
| disease | MESH | Co-infection |
| disease | MESH | cryptococcosis |
| disease | MESH | histoplasmosis |
| disease | IDO | cell |
| disease | MESH | Aspergillosis |