Publication date: Mar 04, 2025

To determine patients’ acceptability, satisfaction and adherence to shorter all-oral multidrug-resistant tuberculosis (MDR-TB) regimen in Tanzania. A two-phase cross-sectional study with data collected within 6 months of Removed Injectable modified Short-course regimens for EXpert MDR-TB (RISE) study implementation and the second phase within 15 months of implementation using the same reference populations. 18 health facilities across eight regions of Tanzania. Rifampicin-resistant TB/MDR-TB patients enrolled in the RISE study. We assessed patients’ acceptability, adherence and satisfaction with the regimen using an interval scale structured questionnaire. The majority of the patients found the shorter oral MDR-TB treatment acceptable, adhered to it well and were generally satisfied. The median score (IQR) for acceptability was 1. 7 (1. 03-2. 00) but it ranged between 1. 3 (1. 3-2) and 1. 7 (1-1. 79) for the first and second phases, respectively. Regarding adherence, the median score (IQR) stood at 4 (3. 67-4. 67) with scores significantly higher in the second phase at 4. 33 (4. 00-5. 007) compared with the first at 4. 67 (4. 00-5. 0), p value=0. 01. The overall satisfaction was high at 1. 5 (1. 33-1. 78) but it ranged between 1. 22 (1. 00-1. 78) and 1. 42 (1. 11-1. 78) for the first and second phases, respectively. Worrying about side effects was statistically associated with adherence (p value

Open Access PDF

Semantics

Original Article