Diabetes mellitus and its determinants among tuberculosis patients in South Gondar Zone health facilities, Northwest Ethiopia.

Diabetes mellitus and its determinants among tuberculosis patients in South Gondar Zone health facilities, Northwest Ethiopia.

Publication date: Feb 17, 2025

Both tuberculosis (TB) and diabetes mellitus (DM) are major global public health concerns, and their prevalence has been rising rapidly in developing countries like Ethiopia. A challenge to TB control could arise from the rising incidence of diabetes and undermine efforts to eradicate the disease. In Ethiopia, particularly in the research region, there is a lack of data regarding TB-DM comorbidity and associated risk factors. To assess the prevalence and determinants of DM in patients with tuberculosis at South Gondar Zone Hospitals in Ethiopia. A facility-based cross-sectional study was conducted in South Gondar Zone health facilities from December, 2023 to May 2024. A total of 1174 participants were selected using a systematic sampling technique. The data were collected using an interviewer-administered structural questionnaire. Previously and newly diagnosed TB at any stage of anti-TB treatment were subjected to a fasting blood sugar measurement. The collected data was entered into EPI Data 3. 1 and exported to SPSS version 24 for analysis. To determine the risk factors, logistic regression was employed. An odds ratio with a 95% CI and a P-value  50 years of age (AOR = 5. 65, 95% CI: 2. 01-16. 35), being married (AOR = 3. 68, 95% CI: 2. 31-7. 2), having no formal education (AOR = 3. 87, 95% CI: 1. 21-9. 2), and being overweight or obese (AOR = 3. 41, 95% CI: 1. 85-8. 62) were significantly associated with diabetes mellitus. The prevalence of DM among TB patients in our study was high. Older age, being married, having no formal education, and being overweight or obese were significant risk factors for TB. Integrating TB and DM screening as well as care delivery in clinical practice is essential to achieving the goal of TB control and improving the health outcomes of both diseases.

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Concepts Keywords
December Diabetes
Diabetes Ethiopia
Ethiopia Fasting blood glucose
Hospitals Risk factors
Rising Tuberculosis

Semantics

Type Source Name
disease MESH Diabetes mellitus
disease MESH tuberculosis
pathway KEGG Tuberculosis
disease MESH comorbidity
disease IDO facility
disease MESH overweight
disease MESH prediabetes
drug DRUGBANK Esomeprazole
disease MESH Extra pulmonary tuberculosis
drug DRUGBANK Dextrose unspecified form
drug DRUGBANK Coenzyme M
drug DRUGBANK Methionine
disease MESH Pulmonary tuberculosis
disease MESH diabetes related complications
disease MESH nutritional deficiencies
disease MESH impaired glucose tolerance
disease MESH complications
disease IDO site
pathway REACTOME Glucose metabolism
disease MESH mental illnesses
disease MESH underweight
drug DRUGBANK Ethanol
disease IDO process
disease IDO reagent
disease MESH marital status
disease MESH educational status
disease IDO history
disease MESH lifestyle
disease MESH obesity
disease MESH Insulin resistance
pathway KEGG Insulin resistance
disease MESH Metabolic Syndrome
disease IDO country
pathway REACTOME Metabolism
disease MESH COVID 19
disease MESH hypertension
disease MESH AIDS
disease MESH hyperglycemia
disease MESH Causes
pathway REACTOME Immune System
pathway REACTOME Reproduction

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