Sequential testing with Xpert MTB/RIF assay for diagnosis of tuberculous meningitis in Maharaj Nakorn Chiang Mai University Hospital.

Ingentiumby Ingentium

In Tuberculosis Literature.

Sequential testing with Xpert MTB/RIF assay for diagnosis of tuberculous meningitis in Maharaj Nakorn Chiang Mai University Hospital.

Publication date: Jan 29, 2025

Early diagnosis and appropriate treatment are essential for reducing morbidity and mortality in tuberculous meningitis (TBM). This study aimed to evaluate the diagnostic performance of the Xpert MTB/RIF assay for the diagnosis of TBM in patients with subacute lymphocytic meningitis. This cross-sectional study included 65 cerebrospinal fluid (CSF) specimens from patients at Maharaj Nakorn Chiang Mai University Hospital, Thailand, between January 2015 and March 2016. Mycobacteria growth indicator tube (MGIT) culture was used as the reference standard. Sensitivity, specificity, and agreement between Xpert MTB/RIF and MGIT culture were calculated. Sequential testing using a TBM score, followed by Xpert MTB/RIF was also analyzed. Xpert MTB/RIF demonstrated 83. 33% sensitivity (95% CI 57. 19-98. 22) and 96. 23% specificity (95% CI 87. 02-99. 54). Agreement between Xpert MTB/RIF and MGIT culture was 93. 85% (p 

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Concepts Keywords
January Meningitis
Lymphocytic Tuberculosis
Maharaj Xpert MTB/RIF
Mycobacteria
Thailand

Semantics

Type Source Name
disease IDO assay
disease MESH tuberculous meningitis
disease MESH morbidity
disease MESH meningitis
disease IDO algorithm
disease MESH Tuberculosis
pathway KEGG Tuberculosis
disease MESH death
disease MESH complications
disease MESH Infectious Diseases
drug DRUGBANK Coenzyme M
drug DRUGBANK Rifampicin
disease MESH convulsions
disease MESH abnormalities
disease MESH pleocytosis
disease IDO protein
disease MESH contraindication
disease MESH malignancies
disease IDO drug susceptibility
drug DRUGBANK Dihydrostreptomycin
drug DRUGBANK Streptomycin
drug DRUGBANK Ethambutol
drug DRUGBANK Isoniazid
disease IDO nucleic acid
disease MESH infection
disease MESH bacterial meningitis
disease MESH lymphoma
disease MESH herpes encephalitis
disease MESH encephalopathy
disease MESH HIV infection
pathway REACTOME HIV Infection
disease MESH hydrocephalus
disease MESH infective endocarditis
drug DRUGBANK Saquinavir
disease MESH Autoimmune diseases
disease MESH COPD
disease IDO history
disease IDO immunodeficiency
disease MESH cryptococcal meningitis
disease MESH central nervous system tuberculosis
disease MESH extrapulmonary tuberculosis
disease MESH pulmonary tuberculosis
pathway REACTOME Reproduction

Original Article

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