Clinical and Mycobacterium tuberculosis strain characteristics of tuberculosis patients with diabetes mellitus in Changping District, Beijing, China.

Publication date: Jan 22, 2025

Diabetes mellitus (DM) is a major risk factor for tuberculosis (TB), However, limited research exists on their clinical and strain characteristics. This study aims to investigate the correlation between these factors in TB-DM patients in Changping District. METHODS: Whole genome sequencing (WGS) and drug susceptibility tests (DST) were performed on culture-positive strains. Spearman correlation analysis was used to examine risk factors and the correlation between lineage, cavities, and hemoptysis in the TB-DM population. The specificity, sensitivity, and confidence intervals for predicting phenotypic drug resistance based on genotypic resistance were calculated. Among the 3924 TB patients, 292 had DM, showing a doubling in the proportion of TB patients with DM over seven years. Among the 144 etiologically positive TB-DM cases treated at the Changping Institute for Tuberculosis Prevention and Treatment, 75% (108/144) of the patients exhibited tuberculosis lesions that formed cavities and 12. 5% (18/144) with hemoptysis. A statistically significant difference in cavity formation across different age groups was observed (r = -0. 198, P 

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Concepts Keywords
Beijing Adolescent
Genome Adult
Mycobacterium Aged
Tuberculosis Antitubercular Agents
Antitubercular Agents
Beijing
China
Diabetes Mellitus
Diabetes mellitus
Drug Resistance, Bacterial
Drug susceptibility testing
Female
Genotype
Humans
Lineage
Male
Microbial Sensitivity Tests
Middle Aged
Mycobacterium tuberculosis
Risk Factors
Tuberculosis
Tuberculosis
Whole Genome Sequencing
Whole genome sequencing
Young Adult

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