Atypical presentation of gouty tophi in a resource-limited setting.

Publication date: Jan 21, 2025

A man in his early 50s from Tanzania presented with chronic nodular skin lesions and joint pain, likely due to gout complicated by obesity, after over 15 years of misdiagnosis and ineffective treatment. Despite various therapies for leprosy, tuberculosis and steroid use, his condition worsened, leading to hyperglycaemia and significant financial strain. Missed opportunities to use simple, low-cost diagnostic tests such as ultrasound and examining nodule fluid for urate crystals led to delays in diagnosis. Instead, unnecessary tests were performed, increasing costs without aiding diagnosis. This case highlights the need to use simple, available diagnostic tests in resource-limited settings before relying on costly investigations that can impose a heavy financial burden on patients. Likewise, it emphasises recognising atypical presentations of gouty tophi, such as isolated soft tissue involvement without joint involvement.

Concepts Keywords
50s Diagnosis, Differential
Obesity Diagnostic Errors
Tanzania Gout
Tuberculosis Gout Suppressants
Ultrasound Gout Suppressants
Humans
Male
Middle Aged
Obesity
Obesity (public health)
Resource-Limited Settings
Rheumatology
Tanzania

Semantics

Type Source Name
drug DRUGBANK Methyprylon
disease MESH joint pain
disease MESH gout
disease MESH obesity
disease MESH misdiagnosis
disease MESH leprosy
disease MESH tuberculosis
pathway KEGG Tuberculosis
drug DRUGBANK Uric Acid

Original Article

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