Micronutrient status and risk of Mycobacterium tuberculosis infection in Indonesian tuberculosis case contacts.

Publication date: Jan 16, 2025

Certain micronutrient levels have been associated with the risk of developing TB disease. We explored the possible association of selected at-risk micronutrient levels with the development of Mycobacterium tuberculosis (M. tb) infection. This cohort study in Bandung, Indonesia, followed Interferon Gamma Release Assay (IGRA) negative TB case contacts with a repeat IGRA test at 3 mo. At baseline, blood was analysed for haemoglobin, 25-hydroxyvitamin D, retinol-binding protein, C-reactive protein, alpha-1-acid glycoprotein, serum transferrin receptor (sTfR), ferritin, zinc and selenium. Total body iron was calculated using ferritin and sTfR status. Associations between case contact micronutrient concentration and IGRA conversion were estimated using Poisson regression. Of 430 contacts, 115 (27%) underwent IGRA conversion. Ferritin concentration (adjusted for inflammation) was positively associated with risk of IGRA conversion (incidence rate ratio [IRR] for ferritin=1. 17; 95% CI 1. 01 to 1. 35; p=0. 03), but other select micronutrients were not. This association held for ferritin in the final multivariable model (IRR=1. 27; 95% CI 1. 09 to 1. 47; p=0. 002). The risk of developing M. tb infection, as defined by IGRA conversion, is associated with increasing ferritin. Interventions in TB case contacts to temporarily reduce iron levels, including considering withholding any iron supplementation, may be worthy of evaluation.

Concepts Keywords
Final iron
Hydroxyvitamin micronutrients
Indonesia Mycobacterium tuberculosis infection
Micronutrient
Tuberculosis

Semantics

Type Source Name
disease MESH Mycobacterium tuberculosis infection
pathway KEGG Tuberculosis
disease MESH infection
pathway REACTOME Release
disease IDO assay
disease IDO blood
drug DRUGBANK Vitamin A
drug DRUGBANK Zinc
drug DRUGBANK Selenium
drug DRUGBANK Iron
disease MESH inflammation

Original Article

Leave a Comment

Your email address will not be published. Required fields are marked *