Asymptomatic lung abscess of aspergillus in a female without previous lung diseases or immunocompromise: a case report.

Publication date: Jan 14, 2025

Chronic pulmonary abscess usually results from bacterial or mycobacterium infection, but rarely from aspergillosis. Chronic pulmonary aspergillosis is usually found in a person with structural lung disease or immunocompromise. Here, we report a case of chronic lung abscess of aspergillosis without immunocompromise, structural lung diseases or even clinical symptoms. A 43-year-old female was found a mass shadow with central liquid anechoic area in the apical posterior segment of the left upper lung lobe by chest computerized tomography for 1 month, but had no any systematic or respiratory complaints. The percutaneous abscess puncture was performed and 30 milliliters of yellow purulent fluid were aspirated from the liquid anechoic area. Then Aspergillus terreus was detected by both fluid culture and metagenomics next-generation sequencing. Interestingly, this patient had no history of tuberculosis or chronic pulmonary diseases. Other immunocompromised conditions were also denied through history inquest and laboratory tests. Ultimately, the catheterization and drainage of the lung abscess and 6 months of antifungal therapy with standard dose of voriconazole brought the woman a favorable outcome. Aspergillus lung abscess can occasionally occur in a person without pre-existent lung cavity and immune suppression, which is prone to misdiagnosis because of the rarity and the symptom-free.

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Concepts Keywords
Aspergillosis Adult
Laboratory Antifungal Agents
Mycobacterium Antifungal Agents
Tomography Aspergillus
Aspergillus
Asymptomatic
Chronic pulmonary aspergillosis
Female
Fungal infection
Humans
Lung
Lung Abscess
Lung abscess
Pulmonary Aspergillosis
Tomography, X-Ray Computed
Voriconazole
Voriconazole

Semantics

Type Source Name
disease MESH lung abscess
disease MESH lung diseases
disease MESH mycobacterium infection
disease MESH aspergillosis
disease MESH pulmonary aspergillosis
disease MESH abscess
disease IDO history
disease MESH tuberculosis
pathway KEGG Tuberculosis
drug DRUGBANK Voriconazole
disease MESH misdiagnosis
disease IDO symptom
disease MESH Infectious Diseases
pathway REACTOME Reproduction
drug DRUGBANK Alpha-1-proteinase inhibitor
disease MESH Fungal infection
disease IDO bacteria
disease IDO production
disease MESH dyspnea
disease MESH weight loss
disease MESH chest pain
disease MESH anemia
disease IDO host
disease MESH infection
disease MESH drug abuse
disease MESH chronic diseases
disease MESH diabetes mellitus
disease MESH kidney diseases
disease MESH autoimmune diseases
disease MESH tumor
drug DRUGBANK Pentaerythritol tetranitrate
disease IDO nucleic acid
disease IDO blood
disease MESH pus
disease IDO assay
disease IDO process
disease IDO immunodeficiency
disease MESH immunocompromised host
drug DRUGBANK Urea
drug DRUGBANK Nitrogen
drug DRUGBANK Creatinine
disease IDO cell
drug DRUGBANK Carboxyamidotriazole
pathway REACTOME Infectious disease
disease IDO infectious disease
drug DRUGBANK Methionine
drug DRUGBANK (S)-Des-Me-Ampa
disease MESH atresia
drug DRUGBANK Scutellaria baicalensis root

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