Publication date: Jan 07, 2025
Antitubercular treatment (ATT) is associated with multiple cutaneous adverse drug reactions. Second-line ATT is also associated with numerous adverse reactions; however, cutaneous reactions are under-reported. Oral drug provocation (ODP) in multidrug-resistant tuberculosis is challenging because of the paucity of time and the risk of developing secondary drug resistance in the case of interrupted medication. In this paper, we report a case of drug reaction with eosinophilia and systemic symptoms caused by cycloserine in an 18-year-old girl, which was confirmed with ODP and a patch test.
| Concepts | Keywords |
|---|---|
| Drug | Adverse |
| Girl | Att |
| Med | Cutaneous |
| Old | Drug |
| Tuberculosis | Eosinophilia |
| Multidrug | |
| Odp | |
| Patch | |
| Reaction | |
| Reactions | |
| Resistant | |
| Symptoms | |
| Systemic | |
| Test | |
| Tuberculosis |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome |
| drug | DRUGBANK | Cycloserine |
| disease | MESH | Multidrug-Resistant Tuberculosis |
| drug | DRUGBANK | 5-amino-1 3 4-thiadiazole-2-thiol |
| disease | MESH | adverse drug reactions |