Pulmonary Tuberculosis and Risk of Lung Cancer: A Systematic Review and Meta-Analysis.

Publication date: Dec 28, 2024

Lung cancer is a leading cause of cancer-related deaths worldwide, with rising incidence in resource-limited settings. Research suggests an increased risk of lung cancer in individuals with a history of pulmonary tuberculosis (TB), but the association needs further clarification. This systematic review aims to provide a more comprehensive understanding of this relationship. We systematically searched the PubMed/Medline, EMBASE, and Scopus databases for relevant studies up to March 15, 2024. The quality of the included studies was assessed using the Joanna Briggs Institute (JBI) critical appraisal checklist. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using either random-effects or fixed-effects models, depending on the level of heterogeneity. All statistical analyses were performed using Comprehensive Meta-Analysis software, version 3. 0. A total of 37 studies were included (9 cohort and 28 case-control). A significant association between prior pulmonary TB and lung cancer was found in both cohort (OR: 2. 3; 95% CI, 1. 4-3. 8) and case-control (OR: 1. 9; 95% CI, 1. 4-2. 5) studies. Subgroup analyses revealed a stronger association in East Asia (OR: 2. 4; 95% CI, 1. 3-4. 1). Our study provides strong evidence of an increased risk of lung cancer following pulmonary TB. The findings emphasize the need for comprehensive public health strategies, including targeted screening, early detection, and smoking cessation. Future studies should investigate the mechanisms linking TB and lung cancer, as well as the effectiveness of integrated prevention programs, particularly in high-burden regions.

Concepts Keywords
Asia Analysis
Cancer Cancer
Databases Ci
March Cohort
Pulmonary Comprehensive
Effects
Included
Increased
Lung
Meta
Pulmonary
Risk
Systematic
Tb
Tuberculosis

Semantics

Type Source Name
disease MESH Pulmonary Tuberculosis
disease MESH Lung Cancer
disease MESH cancer
disease IDO history
disease IDO quality

Original Article

Leave a Comment

Your email address will not be published. Required fields are marked *