A retrospective study of extrapulmonary tuberculosis in the Khuzestan province of southwest Iran between 2002 and 2023.

Publication date: Dec 25, 2024

Worldwide, tuberculosis (TB) is among the most common causes of death. To our knowledge, there has been no study showing the prevalence of EPTB in Khuzestan province. Therefore, the objective of this research was to investigate the prevalence of EPTB in patients with or without pulmonary TB in different cities of Khuzestan province from 2002 to 2023. Additionally, the correlation between patient’s gender, and age groups with the disease was also investigated. In this retrospective study, the existing records in Tuberculosis Regional Reference Laboratory of Khuzestan province related to patients were used. The research was carried out by investigating the archive information in 19 years (from 1st January 2002 to December 30, 2023). All confirmed cases of EPTB and simultaneous EPTB and PTB, based on laboratory results and medical examination were included in the study. Patients with incomplete information and military TB were excluded from the study. Information collected from patients includes age, gender, involved organ, place of residence, and year of disease. A total of 12,900 EPTB-related medical records were extracted from Tuberculosis Regional Reference Laboratories in southwest Iran, Ahvaz. After excluding records, 12,836 clinically diagnosed or laboratory-confirmed tuberculosis patients were included in this study, including 5991 patients with simultaneous PTB and EPTB, and 6845 patients with EPTB only. The mean age of male EPTB patients was 37. 5 years (SD +/- 14. 6), while the mean age of male patients with simultaneous PTB and EPTB was 45. 8 years (SD +/- 15. 3). The mean age of female patients with EPTB only, and with simultaneous PTB and EPTB was 31. 2 years (SD +/- 12. 6), and 31. 5 years respectively. tuberculosis is a systemic disease with different clinical manifestations. This study described different epidemiologic patterns of concurrent EPTB. The proportion of different types of EPTB was simultaneously determined for a group of hospitalized patients and shown to be different with gender and age. This study will likely increase clinicians’ awareness of the disease and help them better address diagnostic challenges and improve treatment outcomes for patients with EPTB.

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Concepts Keywords
Clinicians Adolescent
Iran Adult
Sd14 Aged
Tuberculosis Aged, 80 and over
Child
Child, Preschool
Data analysis
Epidemiology
Extrapulmonary tuberculosis
Female
Humans
Infant
Iran
Male
Middle Aged
Mycobacterium tuberculosis
Prevalence
Retrospective Studies
Tuberculosis
Tuberculosis, Extrapulmonary
Tuberculosis, Pulmonary
Young Adult

Semantics

Type Source Name
disease MESH extrapulmonary tuberculosis
disease MESH tuberculosis
pathway KEGG Tuberculosis
disease MESH causes of death
drug DRUGBANK Tropicamide
pathway REACTOME Reproduction
disease MESH Infectious Diseases
drug DRUGBANK Coenzyme M
disease MESH death
disease MESH meningitis
disease MESH pericarditis
disease MESH AIDS
disease MESH adenitis
disease IDO country
disease IDO algorithm
disease IDO symptom
disease MESH sweating
disease MESH tuberculous lymphadenitis
disease MESH tuberculous meningitis
disease MESH Weight loss
disease MESH Chest pain
disease MESH renal tuberculosis
disease MESH pleuritis
disease MESH pleural effusion
drug DRUGBANK Tretamine
disease MESH pulmonary tuberculosis
disease MESH spinal arachnoiditis
disease IDO site
disease MESH pleural tuberculosis
drug DRUGBANK BCG vaccine
disease IDO immunodeficiency
drug DRUGBANK Trestolone
pathway REACTOME Immune System
disease MESH privacy
disease MESH Malaria
pathway KEGG Malaria
disease IDO assay
disease IDO host

Original Article

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