Plasma ferritin, C-reactive protein, and adenosine deaminase levels in tuberculous lymphadenitis and pleuritis and their role in monitoring treatment response.

Ingentiumby Ingentium

In Tuberculosis Literature.

Plasma ferritin, C-reactive protein, and adenosine deaminase levels in tuberculous lymphadenitis and pleuritis and their role in monitoring treatment response.

Publication date: Dec 02, 2024

We aimed to assess the plasma levels of ferritin, C-reactive protein (CRP), and adenosine deaminase (ADA) at baseline and their utility as biomarkers to monitor response to treatment in extrapulmonary tuberculosis (EPTB) patients. Prospective measurements of ferritin, CRP, and ADA were done in unstimulated plasma samples of 92 EPTB (49 TB lymphadenitis and 43 TB pleuritis) patients registered for anti-TB treatment. Blood samples were taken at the start, 2, and 6 months of treatment, plasma levels of ferritin and CRP were measured by the enzyme-linked immunosorbent assay and ADA levels by kinetic chemistry method at each time point. Data was analyzed using SPSS version 22. Non-parametric tests were used for paired analysis and two groups’ comparison. Spearman’s rank test was used for correlation analysis. A Chi-square test was used for categorical variables. A p-value 

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Concepts Keywords
49tb ADA
Adenosine CRP
Biomarkers EPTB
Spearman Ferritin
Tuberculosis TB lymphadenitis
TB pleuritis
Treatment response

Semantics

Type Source Name
drug DRUGBANK Pegademase bovine
disease MESH tuberculous lymphadenitis
disease MESH pleuritis
disease IDO role
disease MESH extrapulmonary tuberculosis
disease MESH lymphadenitis
disease IDO blood
disease IDO assay
disease MESH Infectious Diseases
pathway REACTOME Reproduction
drug DRUGBANK Trestolone
disease MESH Tuberculosis
pathway KEGG Tuberculosis
disease MESH death
drug DRUGBANK Isoniazid
drug DRUGBANK Rifampicin
drug DRUGBANK Ethambutol
drug DRUGBANK Edetic Acid
drug DRUGBANK Indoleacetic acid
drug DRUGBANK Tretamine
drug DRUGBANK Thymidine monophosphate
disease IDO reagent
drug DRUGBANK Antipyrine
drug DRUGBANK Adenosine
drug DRUGBANK Aniline
disease MESH Lymphocytosis
disease IDO history
disease MESH pleural effusion
disease MESH weight gain
disease MESH weight loss
disease IDO immunodeficiency
drug DRUGBANK Coenzyme M
disease IDO symptom
drug DRUGBANK L-Valine
drug DRUGBANK Iron
drug DRUGBANK Esomeprazole
disease MESH infections
disease IDO host
pathway REACTOME Metabolism
disease MESH meningitis
disease MESH bacterial meningitis
disease IDO infection
disease MESH over diagnosis
disease MESH inflammation
disease MESH ischemic stroke
drug DRUGBANK Pentaerythritol tetranitrate
drug DRUGBANK Testosterone
drug DRUGBANK Hexocyclium
drug DRUGBANK Troleandomycin
disease MESH sepsis
disease IDO pathogen host
disease MESH Lymphadenopathies
disease MESH spinal tuberculosis
disease MESH pulmonary tuberculosis
disease IDO object
disease MESH lymphoma
disease MESH malignant pleural effusion
disease MESH iron deficiency
disease MESH overweight
disease MESH obesity
disease MESH autoimmunity
disease MESH COVID 19
disease MESH influenza

Original Article

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