Determinants of an unfavorable treatment outcome among tuberculosis patients in the Jimma Zone, Southwest Ethiopia.

Publication date: Nov 26, 2024

Tuberculosis (TB) is a major public health challenge in Ethiopia. TB treatment outcomes were suboptimal compared to the expected target of the national TB control Program. The provision of standard anti-TB treatment is the primary component of the directly observed treatment, short-course strategy. The aim of this study was to assess the TB treatment outcomes and the determinants of an unfavorable treatment outcome. The study used a cross-sectional study design at baseline and record review to identify treatment outcomes. A total of 1,161 TB patients were recruited from eight randomly selected districts and one town administration in the Jimma Zone, Ethiopia. Treatment outcomes were grouped into favorable and unfavorable. Of the total participants, 86. 9% had a favorable treatment outcome, and 5. 7% an unfavorable treatment outcome. The rest were transferred out and not recorded cases. Women were more likely to experience an unfavorable treatment outcome [adjusted odds ratio (AOR) = 1. 96, 95% CI 1. 06, 3. 64]. Patients who were perceived to not be stigmatized were less likely to have an unfavorable treatment outcome (AOR = 0. 32, 95% CI 0. 15, 0. 73). Patients who had a monthly income of > 3,500 Ethiopian birr were less likely to have an unfavorable outcome than patients who did not have a regular income (AOR = 0. 04, 95% CI 0. 01, 0. 45). The observed treatment success rate is lower than the World Health Organization’s target of successfully treating > 90% of detected TB cases. It is imperative to ensure that information, education and communication/behavior change communication strategies consider the needs of women and patients with perceived TB stigma. Furthermore, designing locally acceptable and affordable interventions may help to address the financial challenges of TB treatment adherence.

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Concepts Keywords
1161tb Adolescent
Affordable Adult
Ethiopia Aged
Therapy Antitubercular Agents
Tuberculosis Antitubercular Agents
Cross-Sectional Studies
Determinants
Ethiopia
Female
Humans
Male
Middle Aged
Treatment Outcome
Treatment outcomes
Tuberculosis
Tuberculosis
Unfavorable outcome
Young Adult

Semantics

Type Source Name
disease MESH tuberculosis
pathway KEGG Tuberculosis
drug DRUGBANK Spinosad
drug DRUGBANK Esomeprazole
drug DRUGBANK Rifampicin
drug DRUGBANK Isoniazid
drug DRUGBANK Pyrazinamide
drug DRUGBANK Ethambutol
drug DRUGBANK Coenzyme M
drug DRUGBANK Etoperidone
disease MESH education levels
disease MESH diabetes mellitus
disease IDO history
disease MESH HIV infection
pathway REACTOME HIV Infection
disease MESH relapse
disease MESH critically ill
disease IDO facility
disease IDO process
drug DRUGBANK Aspartame
disease MESH treatment failure
disease MESH chronic illness
disease MESH hypertension
disease MESH heart disease
disease MESH kidney disease
drug DRUGBANK Ethanol
drug DRUGBANK Cathine
drug DRUGBANK Cathinone
drug DRUGBANK Dihydroxy(oxo)molybdenum(6+)
disease MESH death
disease MESH infections
disease MESH Marital status
disease MESH AIDS
disease MESH co infection
disease IDO symptom
disease MESH unemployment
pathway REACTOME Immune System
disease MESH COVID 19 pandemic
disease MESH Leprosy
disease MESH pulmonary tuberculosis
disease MESH treatment delay
disease MESH psychological distress
disease IDO quality
disease MESH nutritional status
pathway REACTOME Metabolism
disease MESH SACCADE
pathway REACTOME Reproduction

Original Article

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