Publication date: Jan 01, 2025
To investigate whether the methylation of circulating cell-free DNA (cfDNA) differentiates active tuberculosis (TB) from latent TB infection (LTBI). Patients with pulmonary TB, contacts with LTBI, and healthy controls were enrolled (2018-2021). Plasma cfDNA was extracted, and using a 5-methylcytosine (5mC) DNA ELISA kit, the global methylation of cfDNA (5mC-cfDNA) was measured. 59 TB, 63 LTBI, 39 healthy controls were included. The 5mC-cfDNA level was higher in TB (6. 4 %) than LTBI (4. 1 %) and healthy controls (4. 9 %) (both p
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | tuberculosis |
| pathway | KEGG | Tuberculosis |
| disease | MESH | latent tuberculosis infection |
| pathway | REACTOME | Methylation |
| disease | MESH | infection |
| pathway | REACTOME | DNA methylation |
| disease | MESH | Tuberculosis Pulmonary |