A Clinical Study to Evaluate the Drug-Drug Interaction and Food Effect of Sudapyridine(WX-081) Tablet With Itraconazole and Rifampin in Healthy Chinese Adult Volunteers

Publication date: Nov 20, 2024

The goal of this clinical trial is to learn how Sudapyridine (WX-081) tablets interact with other drugs and how food intake affects its pharmacokinetics in healthy Chinese adults. The main questions it aims to answer are: How does itraconazole (a strong CYP3A inhibitor) affect the pharmacokinetics of Sudapyridine? How does rifampin (a strong CYP3A inducer) affect the pharmacokinetics of Sudapyridine? How does food intake influence the pharmacokinetics of Sudapyridine? Participants will: Take Sudapyridine alone, with itraconazole, with rifampin, and under fed and fasting conditions based on a predefined sequence. Attend multiple clinic visits for blood sample collection and safety evaluations. Researchers will compare the pharmacokinetic parameters of Sudapyridine under these conditions to determine the impact of drug-drug interactions and food.

Concepts Keywords
Chinese Adults
Pharmacokinetic Chinese
Sperm Clinical
Tuberculosis Conditions
Volunteers Cyp3a
Drug
Evaluate
Food
Healthy
Itraconazole
Kg
Participants
Pharmacokinetics
Safety
Sudapyridine

Semantics

Type Source Name
disease MESH Drug Interaction
drug DRUGBANK Itraconazole
drug DRUGBANK Rifampicin
disease IDO blood
disease MESH hematologic diseases
disease MESH acute diseases
disease IDO history
pathway REACTOME Metabolism
disease MESH Pulmonary Tuberculosis
drug DRUGBANK Didanosine

Original Article

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