Publication date: Nov 21, 2024
India’s high tuberculosis (TB) burden is exacerbated by concurrent silicosis, which increases TB susceptibility and worsens treatment outcomes. Limited studies on TB patients with silicosis highlight the need to address this vulnerable group’s specific challenges, particularly to improve diagnosis and management. This retrospective cohort study analyzed survival data from 137 silico-tuberculosis and 2,605 TB-only patients in Khambhat, India, using Kaplan-Meier curves, log-rank tests, and comparisons between Cox proportional hazards and accelerated failure time (AFT) models. The lognormal AFT model, selected for its lowest Akaike Information Criterion (AIC), estimated survival times based on age, gender, HIV status, and prior TB treatment. Among the 2,742 patients, 309 (11%) died within 27 months. Median time from diagnosis to outcome was shorter for deceased patients (1. 7 months) than for censored patients (5. 6 months, p
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Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | tuberculosis |
| pathway | KEGG | Tuberculosis |
| disease | MESH | silicosis |
| disease | IDO | susceptibility |
| drug | DRUGBANK | Silicon dioxide |
| disease | MESH | treatment failure |
| disease | MESH | pneumoconiosis |
| drug | DRUGBANK | Coenzyme M |
| disease | IDO | nucleic acid |
| disease | MESH | ‘death |
| drug | DRUGBANK | Trestolone |
| drug | DRUGBANK | Isoniazid |
| drug | DRUGBANK | Etoperidone |
| disease | IDO | history |
| disease | IDO | immunodeficiency |
| disease | MESH | lung diseases |
| disease | MESH | comorbidity |
| disease | MESH | HIV infection |
| pathway | REACTOME | HIV Infection |
| disease | MESH | complications |
| drug | DRUGBANK | Oxygen |
| disease | MESH | latent infection |
| disease | IDO | symptom |
| disease | IDO | intervention |
| disease | IDO | quality |
| disease | MESH | Pulmonary Tuberculosis |
| drug | DRUGBANK | Gold |
| drug | DRUGBANK | Water |
| disease | MESH | recurrence |
| drug | DRUGBANK | Spinosad |
| disease | MESH | morbidity |
| disease | IDO | site |
| disease | MESH | Aids |
| drug | DRUGBANK | Bedaquiline |
| drug | DRUGBANK | Delamanid |
| disease | MESH | latent tuberculosis |
| drug | DRUGBANK | L-Tyrosine |
| disease | MESH | privacy |
| pathway | REACTOME | Reproduction |