Publication date: Nov 11, 2024
Pulmonary tuberculosis (TB) is a contagious bacterial infection caused by Mycobacterium tuberculosis that primarily affects the lungs. Despite advances in treatment, TB remains a major public health challenge, particularly in developing countries. This retrospective cohort study aimed to identify factors that influence the time to relapse in patients with pulmonary tuberculosis. All smear-positive pulmonary tuberculosis patients (1548 patients) whose data were recorded in the tuberculosis registration system of Golestan University of Medical Sciences and Health Services from March 2014 to March 2019, and followed up until February 2021. To analyze the data, we applied LASSO, MCP, and SCAD penalized Cox models. Based on the AIC and BIC criteria, the MCP penalized model was better than the LASSO and SCAD penalized models. The variables of age at diagnosis (> 35 vs. 35, HR = 2. 77), marital status (married vs. single, HR = 8. 49), chronic renal failure (Yes vs. No, HR = 5. 36), and pre-treatment smear test results (+ 1 vs. 1-9Basil, HR = 0. 65 and + 2 vs. 1-9Basil, HR = 0. 96) influenced time to relapse according to the MCP penalized Cox regression model. Health care systems should focus on identification of factors that influence time to relapse and developing interventions to reduce relapse rates.
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Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | relapse |
| disease | MESH | pulmonary tuberculosis |
| disease | MESH | bacterial infection |
| disease | MESH | tuberculosis |
| pathway | KEGG | Tuberculosis |
| drug | DRUGBANK | Tropicamide |
| disease | MESH | marital status |
| disease | MESH | chronic renal failure |
| pathway | REACTOME | Reproduction |
| disease | MESH | death |
| disease | IDO | infectious agent |
| disease | MESH | COVID 19 |
| disease | MESH | AIDS |
| drug | DRUGBANK | Spinosad |
| disease | MESH | Noncommunicable Diseases |
| disease | MESH | HIV infection |
| pathway | REACTOME | HIV Infection |
| drug | DRUGBANK | Tretamine |
| disease | MESH | delayed treatment |
| disease | IDO | history |
| disease | MESH | drug addiction |
| drug | DRUGBANK | L-Arginine |
| disease | MESH | renal failure |
| disease | MESH | infection |
| disease | IDO | susceptibility |
| pathway | REACTOME | Immune System |
| disease | IDO | intervention |
| drug | DRUGBANK | Ethanol |
| disease | IDO | country |
| disease | MESH | treatment failure |
| drug | DRUGBANK | Serine |
| disease | MESH | chronic kidney disease |