Researchers develop four new regimens to treat people with multidrug-resistant TB meningitis

Researchers develop four new regimens to treat people with multidrug-resistant TB meningitis

Publication date: Aug 19, 2024

In contrast, while bedaquiline brain levels were almost one-fifth the plasma levels, the lung levels were double the amount in the plasma. Only pretomanid achieved therapeutic brain tissue exposures at the standard human oral dosing. Mathematical simulations based on the models were then used to predict which tissue exposures and doses would be necessary to attain therapeutic brain penetration of each antibiotic. “Interestingly, pretomanid brain levels were double the amount in the plasma.

Concepts Keywords
Deadliest Antibiotic
Florida Antibiotics
Medicinenext Bedaquiline
Mice Brain
Tuberculosis Effective
Hopkins
Johns
Linezolid
Lung
Meningitis
Pretomanid
Regimen
Regimens
Tb
Tissue

Semantics

Type Source Name
disease MESH tuberculosis
drug DRUGBANK Pyrazinamide
drug DRUGBANK Moxifloxacin
drug DRUGBANK Sulfamethoxazole
drug DRUGBANK Sutezolid
drug DRUGBANK Tropicamide
disease MESH infectious diseases
pathway KEGG Tuberculosis
disease MESH Infection
disease MESH Inflammation
drug DRUGBANK Bedaquiline
drug DRUGBANK Pretomanid
drug DRUGBANK Linezolid
disease MESH meningitis
disease MESH TB meningitis

Original Article

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