Publication date: Aug 19, 2024
In contrast, while bedaquiline brain levels were almost one-fifth the plasma levels, the lung levels were double the amount in the plasma. Only pretomanid achieved therapeutic brain tissue exposures at the standard human oral dosing. Mathematical simulations based on the models were then used to predict which tissue exposures and doses would be necessary to attain therapeutic brain penetration of each antibiotic. “Interestingly, pretomanid brain levels were double the amount in the plasma.
Concepts | Keywords |
---|---|
Deadliest | Antibiotic |
Florida | Antibiotics |
Medicinenext | Bedaquiline |
Mice | Brain |
Tuberculosis | Effective |
Hopkins | |
Johns | |
Linezolid | |
Lung | |
Meningitis | |
Pretomanid | |
Regimen | |
Regimens | |
Tb | |
Tissue |
Semantics
Type | Source | Name |
---|---|---|
disease | MESH | tuberculosis |
drug | DRUGBANK | Pyrazinamide |
drug | DRUGBANK | Moxifloxacin |
drug | DRUGBANK | Sulfamethoxazole |
drug | DRUGBANK | Sutezolid |
drug | DRUGBANK | Tropicamide |
disease | MESH | infectious diseases |
pathway | KEGG | Tuberculosis |
disease | MESH | Infection |
disease | MESH | Inflammation |
drug | DRUGBANK | Bedaquiline |
drug | DRUGBANK | Pretomanid |
drug | DRUGBANK | Linezolid |
disease | MESH | meningitis |
disease | MESH | TB meningitis |