Tailoring biomaterials for vaccine delivery.

Tailoring biomaterials for vaccine delivery.

Publication date: Aug 12, 2024

Biomaterials are substances that can be injected, implanted, or applied to the surface of tissues in biomedical applications and have the ability to interact with biological systems to initiate therapeutic responses. Biomaterial-based vaccine delivery systems possess robust packaging capabilities, enabling sustained and localized drug release at the target site. Throughout the vaccine delivery process, they can contribute to protecting, stabilizing, and guiding the immunogen while also serving as adjuvants to enhance vaccine efficacy. In this article, we provide a comprehensive review of the contributions of biomaterials to the advancement of vaccine development. We begin by categorizing biomaterial types and properties, detailing their reprocessing strategies, and exploring several common delivery systems, such as polymeric nanoparticles, lipid nanoparticles, hydrogels, and microneedles. Additionally, we investigated how the physicochemical properties and delivery routes of biomaterials influence immune responses. Notably, we delve into the design considerations of biomaterials as vaccine adjuvants, showcasing their application in vaccine development for cancer, acquired immunodeficiency syndrome, influenza, corona virus disease 2019 (COVID-19), tuberculosis, malaria, and hepatitis B. Throughout this review, we highlight successful instances where biomaterials have enhanced vaccine efficacy and discuss the limitations and future directions of biomaterials in vaccine delivery and immunotherapy. This review aims to offer researchers a comprehensive understanding of the application of biomaterials in vaccine development and stimulate further progress in related fields.

Concepts Keywords
Hydrogels Biomaterials
Nanobiotechnology Drug delivery
Successful Vaccine adjuvant
Tailoring Vaccine delivery
Vaccine

Semantics

Type Source Name
pathway REACTOME Release
disease MESH cancer
disease MESH acquired immunodeficiency syndrome
disease MESH influenza
disease MESH virus disease
disease MESH COVID-19
disease MESH tuberculosis
pathway KEGG Tuberculosis
disease MESH malaria
pathway KEGG Malaria
disease MESH hepatitis B
pathway KEGG Hepatitis B

Original Article

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